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Oakes, Scott
One or more keywords matched the following properties of Oakes, Scott
PropertyValue
keywords Cell Death
keywords Cell Signaling
overview Scott Oakes’s laboratory studies how mammalian cells commit “suicide” in response to various forms of damage and what goes wrong with this process in cancer and other diseases. In particular, they focus on a type of stress that occurs when the cell’s protein folding factory—an organelle called the endoplasmic reticulum—is overwhelmed and protein quality control fails. He is actively engaged in developing drugs to control cell fate under these conditions, which have potential to benefit patients with diseases from cancer to neurodegeneration.
One or more keywords matched the following items that are connected to Oakes, Scott
Item TypeName
Concept Antigen-Presenting Cells
Concept Cell Fractionation
Concept Cell Line, Transformed
Concept Cell Differentiation
Concept Cell Membrane
Concept Cells
Concept Cell-Free System
Concept Cell Transformation, Neoplastic
Concept Epithelial Cells
Concept Killer Cells, Natural
Concept HeLa Cells
Concept Cell Proliferation
Concept Calcium Signaling
Concept Embryonic Stem Cells
Concept Jurkat Cells
Concept HEK293 Cells
Concept Vero Cells
Concept Adaptor Proteins, Signal Transducing
Concept NK Cell Lectin-Like Receptor Subfamily K
Concept Cell Line, Tumor
Concept Intracellular Signaling Peptides and Proteins
Concept Cell Line
Concept Cell Survival
Concept Cells, Cultured
Concept Receptors, Antigen, T-Cell
Concept Signal Transduction
Concept Myeloid Cells
Academic Article Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.
Academic Article Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors.
Academic Article Untangling the web: mitochondrial fission and apoptosis.
Academic Article Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.
Academic Article IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
Academic Article Erratum: Proteostasis control by the unfolded protein response.
Academic Article IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.
Academic Article BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.
Academic Article Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases.
Academic Article Multiple defects, including premature apoptosis, prevent Kaposi's sarcoma-associated herpesvirus replication in murine cells.
Academic Article IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.
Academic Article Mitochondria control calcium entry at the immunological synapse.
Academic Article Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.
Academic Article Akt and autophagy cooperate to promote survival of drug-resistant glioma.
Academic Article Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.
Academic Article Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients.
Academic Article Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons.
Academic Article A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis.
Academic Article CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.
Academic Article Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress.
Academic Article Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.
Academic Article A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress.
Academic Article Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells.
Academic Article Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis.
Academic Article Signaling cell death from the endoplasmic reticulum stress response.
Academic Article Allosteric inhibition of the IRE1a RNase preserves cell viability and function during endoplasmic reticulum stress.
Academic Article CPEB4 links the clock and the UPR to protect the liver.
Academic Article Endoplasmic reticulum proteostasis: a key checkpoint in cancer.
Academic Article The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.
Academic Article Proteostasis control by the unfolded protein response.
Grant BAX/BAK control ER-mitochondria apoptotic crosstalk
Grant Signaling Cell Death from the Endoplasmic Reticulum
Grant Molecular Pathology of Cancer
Grant Attenuating ER and oxidative stress signaling to reduce cell degeneration in vivo
Academic Article Parallel Signaling through IRE1a and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival.
Academic Article Structural and functional basis for JAK3-deficient severe combined immunodeficiency.
Academic Article In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction.
Academic Article Interleukin-4 signaling in B lymphocytes from patients with X-linked severe combined immunodeficiency.
Academic Article Endoplasmic Reticulum Stress Signaling in Cancer Cells.
Academic Article Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses.
Academic Article The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.
Academic Article SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1a/XBP1 ER stress pathway in human lung-derived cells.
Academic Article SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells.
Concept Cell Self Renewal
Concept A549 Cells
Concept Myeloid Cell Leukemia Sequence 1 Protein
Academic Article DISSECTING TUMOR TRANSCRIPTIONAL HETEROGENEITY FROM SINGLE-CELL RNA-SEQ DATA BY GENERALIZED BINARY COVARIANCE DECOMPOSITION.
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  • Cell
  • signaling